Cellular tumor antigen p53

P04637 · TP53 · Homo sapiens

Structural Confidence

Very high (>90): 53%

Confident (70-90): 7%

Low (50-70): 10%

Very low (<50): 30%

High confidence

Domain Structure

Composed of a single rigid domain and flexible terminal regions (demo data)

Summary

This is a demo sample report. p53 (TP53) is a tumor suppressor protein that plays a central role in cell cycle regulation and the DNA damage response. According to the AlphaFold structure prediction, the N-terminal and C-terminal regions show low confidence (consistent with intrinsically disordered regions), while the central DNA-binding domain was predicted with high confidence. This data is a sample meant to demonstrate how the site presents a completed report -- real reports generated after payment are written by Gemini based on live data.

Related Literature

p53: guardian of the genome (1992)
Structural basis of p53 tetramerization (2010)
TP53 mutations in human cancers (2021)